Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.62 |
| ▸ | JAK3 | P52333 | 7/20 | 0.50 |
| ▸ | JAK2 | O60674 | 6/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | ROS1 | P08922 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716067 | 0.99 | TBK1 (0.62) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL3795187 | 0.91 | TBK1 (0.70) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL3714974 | 0.86 | TBK1 (0.61) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL15163288 | 0.86 | TBK1 (0.72) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL15163391 | 0.86 | TBK1 (0.72) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL3716065 | 0.85 | TBK1 (0.62) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL1285266 | 0.83 | TBK1 (0.88) | TBK1JAK3TYK2AURKAPDPK1 | |
| SCHEMBL1284996 | 0.82 | TBK1 (0.90) | TBK1JAK3TYK2AURKAPDPK1 | |
| SCHEMBL15163478 | 0.80 | CDK4 (0.53) | TBK1JAK3JAK2TYK2AURKA | |
| SCHEMBL15163250 | 0.80 | TBK1 (0.82) | TBK1JAK3JAK2TYK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |