Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709521 | 0.84 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2AXLNR4A2 | |
| SCHEMBL3714670 | 0.83 | KDM4E (0.45) | CYP19A1KDM4EDHODHGAAHTT | |
| SCHEMBL13659554 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL29715210 | 0.76 | MAPK8 (0.53) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL21801215 | 0.76 | MAPK8 (0.53) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL30694782 | 0.74 | ALDH1A1 (0.54) | AXLNR4A2KDM4EALDH1A1GLA | |
| SCHEMBL28135495 | 0.74 | MAPK8 (0.49) | NR4A2KDM4EALDH1A1GLAGAA | |
| SCHEMBL31547769 | 0.73 | SMN1; SMN2 (0.54) | CYP19A1CYP11B1CYP11B2KDM4EDHODH | |
| SCHEMBL3515844 | 0.73 | NR4A2 (0.57) | CYP19A1CYP11B1CYP11B2NR4A2ALDH1A1 | |
| SCHEMBL16131073 | 0.73 | KDM4E (0.55) | AXLNR4A2PLA2G2AKDM4EDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |