Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187729 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1TSHRHIF1AEPAS1 | |
| SCHEMBL3709758 | 0.91 | HDAC3 (0.47) | MMP2MMP8MMP13 | |
| SCHEMBL13188540 | 0.83 | HDAC1 (0.53) | SMN1; SMN2MAPK1TSHRHIF1AEPAS1 | |
| SCHEMBL3713943 | 0.82 | MAPK1 (0.45) | SMN1; SMN2MAPK1MMP2MMP8MMP13 | |
| SCHEMBL3711281 | 0.82 | ABL1 (0.45) | SMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL3715918 | 0.81 | MAPK1 (0.45) | SMN1; SMN2MAPK1MMP2MMP8MMP13 | |
| SCHEMBL3720699 | 0.81 | MAPK1 (0.47) | SMN1; SMN2MAPK1MMP2MMP8MMP13 | |
| SCHEMBL3712370 | 0.80 | ACP1 (0.47) | SMN1; SMN2TSHRHIF1AEPAS1KMT2A | |
| SCHEMBL3713515 | 0.80 | MAPK1 (0.47) | SMN1; SMN2MAPK1MMP2MMP8MMP13 | |
| SCHEMBL13188498 | 0.80 | HDAC1 (0.49) | MMP2MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |