Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | STAT6 | P42226 | 12/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912926 | 0.92 | STAT6 (0.56) | JAK3JAK2JAK1STAT6EGFR | |
| SCHEMBL912925 | 0.92 | STAT6 (0.56) | JAK3JAK2JAK1STAT6EGFR | |
| SCHEMBL913718 | 0.92 | STAT6 (0.56) | JAK3JAK2JAK1STAT6EGFR | |
| SCHEMBL913204 | 0.86 | STAT6 (0.61) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL913205 | 0.86 | STAT6 (0.61) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3722244 | 0.83 | ULK1 (0.61) | JAK3JAK2JAK1STAT6EGFR | |
| SCHEMBL913671 | 0.82 | SYK (0.52) | EGFRSYKNPC1POLBSMN1; SMN2 | |
| SCHEMBL913673 | 0.82 | SYK (0.52) | EGFRSYKNPC1POLBSMN1; SMN2 | |
| SCHEMBL913757 | 0.82 | JAK3 (0.64) | JAK3JAK2JAK1STAT6EGFR | |
| SCHEMBL3715974 | 0.80 | JAK3 (0.55) | JAK3JAK2JAK1STAT6EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |