Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715254 | 1.00 | MCL1 (0.33) | MCL1L3MBTL1MAPK1PREPHPGD | |
| SCHEMBL1616974 | 0.92 | L3MBTL1 (0.38) | L3MBTL1PREPHPGD | |
| SCHEMBL1616973 | 0.92 | L3MBTL1 (0.38) | L3MBTL1PREPHPGD | |
| SCHEMBL3665190 | 0.85 | — | — | |
| SCHEMBL1615855 | 0.82 | TSHR (0.35) | L3MBTL1MAPK1HPGD | |
| SCHEMBL1615856 | 0.82 | TSHR (0.35) | L3MBTL1MAPK1HPGD | |
| SCHEMBL1617404 | 0.80 | MCL1 (0.47) | MCL1L3MBTL1MAPK1PREPHPGD | |
| SCHEMBL415897 | 0.78 | HPGD (0.48) | MCL1L3MBTL1MAPK1PREPHPGD | |
| SCHEMBL3662314 | 0.75 | TLR4 (0.39) | MCL1MAPK1HPGD | |
| SCHEMBL1616198 | 0.72 | MAPT (0.41) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |