Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713710 | 1.00 | KDM5A (0.44) | KDM5AVNN1POLBGAAJAK2 | |
| SCHEMBL29145756 | 1.00 | KDM5A (0.44) | KDM5AVNN1POLBGAAJAK2 | |
| SCHEMBL29145778 | 0.95 | VNN1 (0.43) | KDM5AVNN1POLBGAAJAK2 | |
| SCHEMBL29145744 | 0.94 | VNN1 (0.42) | KDM5AVNN1POLBGAAKMT2A | |
| SCHEMBL29145745 | 0.94 | VNN1 (0.42) | KDM5AVNN1POLBGAAKMT2A | |
| SCHEMBL21192936 | 0.89 | KDM5A (0.40) | KDM5AVNN1POLBGAAKMT2A | |
| SCHEMBL21193141 | 0.89 | KDM5A (0.40) | KDM5AVNN1POLBGAAKMT2A | |
| SCHEMBL21192934 | 0.89 | KDM5A (0.40) | KDM5AVNN1POLBGAAKMT2A | |
| SCHEMBL15793672 | 0.89 | KDM5A (0.40) | KDM5AVNN1POLBGAAKMT2A | |
| SCHEMBL23392344 | 0.81 | AKR1C3 (0.39) | KDM5AVNN1POLBGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117480162-A | Compounds for the treatment or prophylaxis of PRMT5 mediated diseases | 阿古诺治疗有限公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2010091721-A1 | 3 -SUBSTITUTED 1-ARYLSULFONYLPIPERIDINE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |