Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 20/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | HTR2C | P28335 | 2/20 | 0.64 |
| ▸ | HTR2B | P41595 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712397 | 0.93 | HRH1 (0.57) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3714703 | 0.92 | KCNH2 (0.56) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3716823 | 0.89 | KCNH2 (0.57) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3712757 | 0.88 | KCNH2 (0.58) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3708676 | 0.86 | HRH3 (0.67) | HRH1KCNH2CYP2D6HTR2C | |
| SCHEMBL3708250 | 0.85 | KCNH2 (0.53) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL1148962 | 0.83 | HRH1 (0.77) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3708439 | 0.83 | HRH3 (0.55) | HRH1KCNH2CYP2D6HTR2C | |
| SCHEMBL3711533 | 0.83 | HRH1 (0.74) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL1148515 | 0.83 | HRH1 (0.76) | HRH1KCNH2CYP3A4CYP2D6CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | claimed |
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |