Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 19/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711508 | 0.93 | HRH1 (0.64) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL3720054 | 0.86 | HRH3 (0.72) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL2854545 | 0.85 | HRH3 (1.00) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL3711500 | 0.85 | HRH1 (0.56) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| Formic Acid SCHEMBL3710295 | 0.84 | HRH3 (0.70) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL3715465 | 0.83 | HRH1 (0.67) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3713221 | 0.80 | HRH3 (0.60) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL2852768 | 0.79 | HRH3 (1.00) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL3709424 | 0.78 | HRH3 (0.54) | HRH1KCNH2HRH3ADRA1AADRA1B | |
| SCHEMBL3710291 | 0.77 | HRH3 (0.59) | HRH1KCNH2HRH3ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | claimed |
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |