Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.74 |
| ▸ | KDR | P35968 | 4/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | AXL | P30530 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411010 | 0.88 | MET (0.81) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL1882872 | 0.86 | MET (0.84) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL3457986 | 0.85 | MET (1.00) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL371908 | 0.83 | MET (0.71) | METKDR | |
| SCHEMBL1879811 | 0.83 | MET (0.78) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL12444041 | 0.83 | MET (0.73) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL1484298 | 0.82 | MET (0.69) | METKDRPDGFRA | |
| SCHEMBL5145179 | 0.82 | MET (0.69) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL371762 | 0.82 | MET (0.69) | METKDR | |
| SCHEMBL1876439 | 0.82 | MET (0.76) | METKDRPDGFRBPDGFRAAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |