Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715890 | 1.00 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1NPC1RAB9AMAPT | |
| SCHEMBL16388413 | 0.90 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1NPC1RAB9AMAPT | |
| SCHEMBL16388043 | 0.89 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1MAPTALDH1A1LMNA | |
| Potassium Ion SCHEMBL657320 | 0.86 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1MAPTALDH1A1LMNA | |
| SCHEMBL655367 | 0.86 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1RAB9AMAPTALDH1A1 | |
| SCHEMBL657886 | 0.85 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1LMNA | |
| SCHEMBL656133 | 0.83 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1MAPTALDH1A1LMNA | |
| SCHEMBL656132 | 0.83 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1MAPTALDH1A1LMNA | |
| SCHEMBL656515 | 0.78 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1RAB9AMAPT | |
| SCHEMBL658893 | 0.77 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993556-B2 | Resorcinol derivatives as HSP90 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-31 | — | — | US | disclosed |
| EP-2421833-B1 | RESORCINOL DERIVATIVES AS HSP90 INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-01-14 | — | — | EP | disclosed |
| WO-2010121963-A1 | RESORCINOL DERIVATIVES AS HSP90 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-10-28 | — | — | WO | disclosed |