Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913477 | 0.74 | CCNT1 (0.59) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL9495103 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDMAPTALOX12MAPK1 | |
| SCHEMBL3722314 | 0.71 | HDAC3 (0.51) | SMN1; SMN2HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL913874 | 0.70 | CCNT1 (0.57) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL913873 | 0.70 | CCNT1 (0.57) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL913932 | 0.69 | CCNT1 (0.55) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL913674 | 0.69 | CCNT1 (0.55) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL913675 | 0.69 | CCNT1 (0.55) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL11412031 | 0.69 | SMN1; SMN2 (0.64) | SMN1; SMN2HPGDMAPTALOX12MAPK1 | |
| SCHEMBL913597 | 0.68 | CCNT1 (0.57) | CCNT1CCNE1CDK2CDK9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |