Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23709776 | 0.81 | AR (0.41) | HSD17B10TSHRARCYP3A4 | |
| SCHEMBL3720506 | 0.78 | TP53 (0.46) | HSD17B10ESR2ARMAPK1CYP3A4 | |
| SCHEMBL9525070 | 0.77 | MCL1 (0.52) | HSD17B10TSHRCA2CA1ESR2 | |
| SCHEMBL536362 | 0.76 | HSD17B10 (0.54) | HSD17B10TSHRCA2CA1ESR2 | |
| SCHEMBL3716721 | 0.76 | ALOX15 (0.45) | ARESR1ALDH1A1ALOX12HIF1A | |
| SCHEMBL20384243 | 0.76 | AR (0.40) | TSHRARALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10415028 | 0.76 | TSHR (0.45) | HSD17B10TSHRCA2CA1ESR2 | |
| SCHEMBL1018879 | 0.74 | TSHR (0.52) | HSD17B10TSHRCA2CA1ALDH1A1 | |
| SCHEMBL9361475 | 0.73 | EPHX1 (0.43) | HSD17B10TSHRARMAPK1CYP3A4 | |
| SCHEMBL11012502 | 0.72 | HSD17B10 (0.50) | HSD17B10TSHRCA2CA1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |