Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 18/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056078 | 1.00 | CTSS (0.52) | CTSSCTSLCTSBCTSKRBP4 | |
| SCHEMBL3065852 | 0.88 | CTSS (0.48) | CTSSCTSLCTSBCTSK | |
| SCHEMBL3066401 | 0.86 | CTSS (0.55) | CTSSCTSLCTSBCTSKRBP4 | |
| SCHEMBL3723049 | 0.86 | CTSS (0.55) | CTSSCTSLCTSBCTSKRBP4 | |
| SCHEMBL3719516 | 0.82 | CTSS (0.50) | CTSSCTSLCTSBCTSKRBP4 | |
| SCHEMBL3055416 | 0.82 | CTSS (0.50) | CTSSCTSLCTSBCTSKRBP4 | |
| SCHEMBL695615 | 0.82 | CTSS (0.61) | CTSSCTSLCTSB | |
| SCHEMBL3065711 | 0.81 | CTSS (0.56) | CTSSCTSLCTSBCTSK | |
| SCHEMBL3718920 | 0.81 | CTSS (0.56) | CTSSCTSLCTSBCTSK | |
| SCHEMBL697419 | 0.81 | CTSS (0.49) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |