Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 14/20 | 0.37 |
| ▸ | OXTR | P30559 | 2/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714952 | 0.98 | AVPR1B (0.37) | AVPR1BOXTRAVPR1AKDM4EALDH1A1 | |
| SCHEMBL3715725 | 0.95 | AVPR1B (0.37) | AVPR1BOXTRAVPR1AKDM4EALDH1A1 | |
| SCHEMBL3715576 | 0.94 | AVPR1B (0.44) | AVPR1BOXTRAVPR1AAVPR2 | |
| SCHEMBL3715687 | 0.92 | KMT2A (0.36) | AVPR1BOXTRAVPR1AKDM4EALDH1A1 | |
| SCHEMBL3711797 | 0.92 | AVPR1B (0.44) | AVPR1BOXTRAVPR1AAVPR2 | |
| SCHEMBL15279958 | 0.92 | ALDH1A1 (0.37) | AVPR1BOXTRAVPR1AKDM4EALDH1A1 | |
| SCHEMBL15157790 | 0.91 | AVPR1B (0.40) | AVPR1BOXTRAVPR1AKDM4EALDH1A1 | |
| SCHEMBL15157816 | 0.91 | AVPR1B (0.40) | AVPR1BOXTRAVPR1AAVPR2 | |
| SCHEMBL3719353 | 0.90 | KMT2A (0.36) | AVPR1BOXTRAVPR1AKDM4EALDH1A1 | |
| SCHEMBL3720379 | 0.89 | AVPR1B (0.45) | AVPR1BOXTRAVPR1AAVPR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231644-B1 | 5,6-Disubstituted oxindole derivatives and their use in the manufacture of a medicament for the treatment of vasopressin-dependent diseases | ABBVIE DEUTSCHLAND (DE) | 2014-01-15 | — | — | EP | disclosed |
| EP-2623504-A1 | 5,6-Disubstituted oxindole derivatives and their use in the manufacture of a medicament for the treatment of vasopressin-dependent diseases | Abbott GmbH & Co. KG (DE) | 2013-08-07 | — | — | EP | disclosed |
| EP-2231644-A2 | 5,6-DISUBSTITUTED OXINDOLE-DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSINE-DEPENDENT DISEASES | Abbott GmbH & Co. KG (DE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009071690-A2 | 5,6-DISUBSTITUTED OXINDOLE-DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSINE-DEPENDENT DISEASES | ABBOTT GMBH & CO. KG (DE) | 2009-06-11 | — | — | WO | disclosed |