Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240335 | 0.85 | NPC1 (0.70) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL2242957 | 0.85 | TP53 (0.62) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL4034648 | 0.84 | MAPT (0.63) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL4034654 | 0.84 | MAPT (0.63) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL3953026 | 0.83 | MAPT (0.62) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL3953020 | 0.83 | MAPT (0.62) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL2247720 | 0.80 | MAPT (0.78) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL2247792 | 0.79 | NPC1 (0.64) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL3947178 | 0.78 | TP53 (0.64) | TP53MAPTTHRBSMN1; SMN2KDM4E | |
| SCHEMBL3716999 | 0.78 | UTRN (0.74) | TP53MAPTTHRBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010112091-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-10-07 | — | — | WO | claimed |