Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 10/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | THRB | P10828 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | AGPAT2 | O15120 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242957 | 0.85 | TP53 (0.62) | TP53MAPTTHRBKDRAGPAT2 | |
| SCHEMBL2247720 | 0.83 | MAPT (0.78) | TP53MAPTTHRBPOLBRXFP1 | |
| SCHEMBL2240335 | 0.82 | NPC1 (0.70) | TP53MAPTTHRBPOLBSMN1; SMN2 | |
| SCHEMBL2247182 | 0.82 | AGPAT2 (0.74) | TP53MAPTKDRAGPAT2POLB | |
| SCHEMBL4034648 | 0.80 | MAPT (0.63) | TP53MAPTTHRBKDRSMN1; SMN2 | |
| SCHEMBL4034654 | 0.80 | MAPT (0.63) | TP53MAPTTHRBKDRSMN1; SMN2 | |
| SCHEMBL3953026 | 0.79 | MAPT (0.62) | TP53MAPTTHRBKDRSMN1; SMN2 | |
| SCHEMBL3953020 | 0.79 | MAPT (0.62) | TP53MAPTTHRBKDRSMN1; SMN2 | |
| SCHEMBL7779128 | 0.78 | MAPT (0.75) | TP53MAPTTHRBPOLBRXFP1 | |
| SCHEMBL3716583 | 0.78 | TP53 (0.61) | TP53MAPTTHRBPOLBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009021750-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-02-19 | — | — | WO | disclosed |