Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11042558 | 0.90 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL17503485 | 0.89 | BID (0.43) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL2516051 | 0.87 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL14786046 | 0.87 | BID (0.46) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL31500502 | 0.87 | BID (0.46) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL4024006 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3673649 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL22653038 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1MAPTCYP1A2GRM5 | |
| SCHEMBL10932333 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL31252478 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424155-A | Method for producing carbonate ester and catalyst structure for producing carbonate ester | 日本制铁株式会社 | 2021-02-26 | — | — | CN | disclosed |
| CN-105308036-B | The Compounds and methods for and its indication adjusted for kinases | 普莱希科公司 | 2019-06-21 | — | — | CN | disclosed |
| US-9815811-B2 | Inhibitors of the kynurenine pathway | CURADEV PHARMA, PVT. LTD. (IN) | 2017-11-14 | — | — | US | disclosed |
| US-20160046596-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PRIVATE LTD. (IN) | 2016-02-18 | — | — | US | disclosed |
| WO-2010131145-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |
| EP-0674176-B1 | Luminescent rhenium complexes and methods of production | IGEN INT INC (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6468741-B1 | Electrochemiluminescent rhenium moieties | IGEN INTERNATIONAL, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5811236-A | QUANTITATIVE, QUALITATIVE ANALYSIS | IGEN INTERNATIONAL, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |
| US-5716781-A | FORMING A SOLUTION CONTAINING AN ANALYTE COMPRISING FIRST CHEMILUMINESCENT COMPLEX AND AN INTERNAL STANDARD CONTAINING OSMIUM BIPYRIDYL COMPLEX, INDEPENDENTLY MEASURING ELECTROLUMINESCENCE EMITTED BY ANALYTE AND STANDARD | IGEN INTERNATIONAL INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5591581-A | Electrochemiluminescent rhenium moieties and methods for their use | IGEN, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0339086-B1 | ELECTROCHEMILUMINESCENT RHENIUM MOIETIES AND METHODS | IGEN INC (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0674176-A1 | Electrochemiluminescent rhenium moieties and methods of production | IGEN, INC. (US) | 1995-09-27 | — | — | EP | disclosed |
| EP-0339086-A4 | ELECTROCHEMILUMINESCENT RHENIUM MOIETIES AND METHODS. | IGEN INC (US) | 1990-02-20 | — | — | EP | disclosed |
| EP-0339086-A1 | ELECTROCHEMILUMINESCENT RHENIUM MOIETIES AND METHODS | IGEN, INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| WO-1989004302-A1 | ELECTROCHEMILUMINESCENT RHENIUM MOIETIES AND METHODS | IGEN, INC. (US) | 1989-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046596-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | IDO1, KYNU, IDO2 | KDM4E 1209/4885ALDH1A1 911/4885HPGD 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.