Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25177371 | 0.89 | KDM4E (0.54) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL3536274 | 0.83 | DPP4 (0.44) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL3713237 | 0.82 | KDM4E (0.48) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL25177366 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL4507101 | 0.80 | KDM4E (0.46) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL3709331 | 0.80 | AKT1 (0.50) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL4510189 | 0.78 | MAPT (0.41) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL25117818 | 0.76 | KDM4E (0.50) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL13232459 | 0.74 | KDM4E (0.52) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 | |
| SCHEMBL2792352 | 0.74 | MAPT (0.42) | ALDH1A1HSD17B10HPGDL3MBTL1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |