Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.50 |
| ▸ | AKT2 | P31751 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706568 | 0.82 | AKT1 (0.50) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3708211 | 0.80 | AKT1 (0.54) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3716845 | 0.80 | ALDH1A1 (0.48) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10071025 | 0.69 | LMNA (0.44) | ALDH1A1HPGDHSD17B10L3MBTL1TSHR | |
| SCHEMBL25177371 | 0.69 | KDM4E (0.54) | ALDH1A1HPGDHSD17B10L3MBTL1TSHR | |
| SCHEMBL4251045 | 0.69 | L3MBTL1 (0.53) | ALDH1A1L3MBTL1ALPLKDM4EKMT2A | |
| SCHEMBL22105272 | 0.69 | TGFBR1 (0.48) | ALDH1A1HPGDHSD17B10TSHRCASP1 | |
| SCHEMBL3804796 | 0.69 | TGFBR1 (0.41) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3340790 | 0.69 | ALPL (0.53) | ALDH1A1HPGDL3MBTL1ALPLSMN1; SMN2 | |
| SCHEMBL31547134 | 0.68 | POLB (0.39) | ALDH1A1HPGDHSD17B10L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |