Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723022 | 0.88 | MTOR (0.54) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3721931 | 0.86 | MTOR (0.52) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3723774 | 0.85 | MTOR (0.61) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3722849 | 0.85 | MTOR (0.60) | MTORPIK3CA | |
| SCHEMBL3723157 | 0.82 | MTOR (0.55) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3729716 | 0.81 | MTOR (0.55) | MTORPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL3723269 | 0.80 | MTOR (0.54) | MTORPIK3CA | |
| SCHEMBL3718606 | 0.79 | MTOR (0.60) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3728850 | 0.79 | MTOR (0.54) | MTORPIK3CA | |
| SCHEMBL3725816 | 0.79 | MTOR (0.56) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |