Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.70 |
| ▸ | LMNA | P02545 | 6/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | STAT1 | P42224 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717813 | 0.88 | ALDH1A1 (0.68) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL14096564 | 0.86 | ALDH1A1 (0.82) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL14096575 | 0.86 | ALDH1A1 (0.70) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL677855 | 0.86 | TP53 (0.74) | ALDH1A1LMNANPC1RAB9APOLB | |
| SCHEMBL3053761 | 0.85 | ALDH1A1 (0.68) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL18606716 | 0.85 | ALDH1A1 (0.74) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL14096552 | 0.84 | ALDH1A1 (0.74) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL13453917 | 0.83 | ALDH1A1 (0.69) | ALDH1A1ALOX12SMN1; SMN2LMNANPC1 | |
| SCHEMBL24799815 | 0.83 | EPHX1 (0.78) | ALDH1A1ALOX12SMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3718954 | 0.83 | SMN1; SMN2 (0.68) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | disclosed |
| EP-2440522-B1 | AROYLTHIOUREA AND ARYLTHIOCARBONYLUREA DERIVATIVES | UNIV DUNDEE (GB) | 2014-11-12 | — | — | EP | disclosed |
| US-20120149778-A1 | COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE | 2012-06-14 | — | — | US | disclosed |
| WO-2010142956-A2 | COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149778-A1 | COMPOUNDS | AR, NR5A1, NAT1 | ALDH1A1 253/4885ALOX12 511/4885SMN1; SMN2 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.