Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 12/20 | 0.47 |
| ▸ | KHK | P50053 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724694 | 0.86 | MDM2 (0.40) | MAP3K12MAPK1HSD17B10CTSSCTSK | |
| SCHEMBL3727036 | 0.81 | SCN9A (0.51) | MAP3K12KHKHSD17B10MCHR1 | |
| SCHEMBL3717819 | 0.81 | SCN9A (0.51) | MAP3K12KHKHSD17B10MCHR1 | |
| SCHEMBL3727334 | 0.81 | SCN9A (0.51) | MAP3K12KHKHSD17B10MCHR1 | |
| SCHEMBL3724664 | 0.78 | HRH4 (0.57) | MAPK1HSD17B10 | |
| SCHEMBL3722161 | 0.77 | HRH4 (0.53) | MAPK1HSD17B10 | |
| SCHEMBL3720582 | 0.77 | HRH4 (0.45) | MAPK1HSD17B10MCHR1 | |
| SCHEMBL3797918 | 0.76 | HRH4 (0.44) | MAPK1HSD17B10CTSSCTSK | |
| SCHEMBL3720932 | 0.76 | IDH2 (0.44) | MAPK1HSD17B10CTSSCTSK | |
| SCHEMBL3727182 | 0.76 | HSD17B10 (0.41) | MAPK1HSD17B10MCHR1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |