Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724664 | 0.86 | HRH4 (0.57) | KMT2AALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL3797918 | 0.84 | HRH4 (0.44) | KMT2ACTSSCTSKALDH1A1KDM4E | |
| SCHEMBL3725420 | 0.83 | HSD17B10 (0.50) | KMT2AATMALDH1A1KDM4EGAA | |
| SCHEMBL3718066 | 0.83 | HRH4 (0.43) | KMT2ACTSSCTSKALDH1A1KDM4E | |
| SCHEMBL3722161 | 0.82 | HRH4 (0.53) | KMT2AALDH1A1KDM4EMAPK1HSD17B10 | |
| SCHEMBL3721777 | 0.81 | HRH3 (0.42) | KMT2ACTSSCTSKALDH1A1KDM4E | |
| SCHEMBL3721032 | 0.81 | CYP1A2 (0.44) | KMT2AATMALDH1A1KDM4EPOLB | |
| SCHEMBL3721072 | 0.81 | CYP11B2 (0.46) | KMT2ACTSSCTSKALDH1A1KDM4E | |
| SCHEMBL3727016 | 0.80 | CASP1 (0.53) | ALDH1A1KDM4EPOLBCASP1CASP4 | |
| SCHEMBL3724014 | 0.79 | HRH4 (0.43) | KMT2ACTSSCTSKALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |