Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.74 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | PLAT | P00750 | 1/20 | 0.55 |
| ▸ | KIF11 | P52732 | 5/20 | 0.54 |
| ▸ | ERN1 | O75460 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.52 |
| ▸ | CCR6 | P51684 | 1/20 | 0.52 |
| ▸ | AGXT | P21549 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3722990 | 0.98 | DHODH (0.72) | DHODHPLGPLAUPLATKIF11 | |
| SCHEMBL3727414 | 0.88 | PLG (0.60) | DHODHPLGPLAUPLATKIF11 | |
| SCHEMBL1348553 | 0.88 | DHODH (0.60) | DHODHPLGPLAUPLATKIF11 | |
| SCHEMBL30141887 | 0.87 | DHODH (0.61) | DHODHPLGPLAUPLATKIF11 | |
| SCHEMBL29917363 | 0.85 | DHODH (0.71) | DHODHKIF11PDK2HDAC2P2RY14 | |
| SCHEMBL177453 | 0.85 | DHODH (0.71) | DHODHKIF11PDK2HDAC2P2RY14 | |
| SCHEMBL3726477 | 0.84 | DHODH (0.59) | DHODHPLGPLAUPLATKIF11 | |
| SCHEMBL6999225 | 0.84 | DHODH (0.63) | DHODHERN1PARP1 | |
| SCHEMBL893254 | 0.83 | DHODH (0.57) | DHODHKIF11HDAC2SYK | |
| SCHEMBL3018101 | 0.83 | DHODH (0.57) | DHODHPLGPLAUPLATKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |