Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.63 |
| ▸ | PARP1 | P09874 | 7/20 | 0.61 |
| ▸ | ERN1 | O75460 | 2/20 | 0.61 |
| ▸ | KMO | O15229 | 1/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.57 |
| ▸ | TDP2 | O95551 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431097 | 0.98 | PARP1 (0.64) | DHODHPARP1ERN1KMOPRSS1 | |
| SCHEMBL31422694 | 0.98 | PARP1 (0.64) | DHODHPARP1ERN1KMOPRSS1 | |
| SCHEMBL29788172 | 0.96 | DHODH (0.70) | DHODHPARP1ERN1KMOPRSS1 | |
| SCHEMBL43553 | 0.96 | DHODH (0.70) | DHODHPARP1ERN1KMOPRSS1 | |
| Hydrochloric Acid SCHEMBL3973404 | 0.94 | DHODH (0.68) | DHODHPARP1ERN1KMOPRSS1 | |
| Hydrochloric Acid SCHEMBL30628442 | 0.94 | DHODH (0.68) | DHODHPARP1ERN1KMOPRSS1 | |
| SCHEMBL29941476 | 0.94 | DHODH (0.68) | DHODHPARP1ERN1KMOPRSS1 | |
| SCHEMBL2589651 | 0.94 | ERN1 (0.60) | DHODHPARP1ERN1KMOTDP2 | |
| Bromide SCHEMBL30159854 | 0.94 | DHODH (0.68) | DHODHPARP1ERN1KMOPRSS1 | |
| Hydrogen Sulfide SCHEMBL27914334 | 0.94 | DHODH (0.68) | DHODHPARP1ERN1KMOPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440528-A | Fourth Ring Bu Luomo structural domain inhibitor | 艾伯维公司 | 2018-08-24 | — | — | CN | claimed |
| CN-105026403-B | Tetracyclic Bromodomain Inhibitors | 艾伯维公司 | 2018-05-18 | — | — | CN | claimed |
| CN-105026403-A | Tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-11-04 | — | — | CN | claimed |
| EP-1268486-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074823-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | claimed |
| CN-108440528-A | Fourth Ring Bu Luomo structural domain inhibitor | 艾伯维公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105026403-B | Tetracyclic Bromodomain Inhibitors | 艾伯维公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-105026403-A | Tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-11-04 | — | — | CN | disclosed |
| CN-101541811-B | Pyrazolopyrimidine Derivatives | DAIICHI SANKYO CO LTD | 2014-07-09 | — | — | CN | disclosed |
| CN-101541811-A | Pyrazolopyrimidine Derivatives | DAIICHI SANKYO CO LTD (JP) | 2009-09-23 | — | — | CN | disclosed |
| EP-1268486-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074823-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | disclosed |