Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628721 | 0.82 | KDM4E (0.51) | GAAKDM4EL3MBTL1PTGS1PTGS2 | |
| SCHEMBL118089 | 0.77 | MEN1 (0.44) | L3MBTL1NPC1RAB9AKMT2A | |
| SCHEMBL3498219 | 0.73 | SMN1; SMN2 (0.47) | GAAKDM4EEGLN1NPC1RAB9A | |
| SCHEMBL14655219 | 0.73 | KDM4E (0.47) | KDM4EL3MBTL1PTGS1PTGS2NPC1 | |
| SCHEMBL3340526 | 0.73 | PTGS1 (0.41) | GAAKDM4EL3MBTL1PTGS1PTGS2 | |
| SCHEMBL3369735 | 0.73 | PTGS1 (0.41) | GAAKDM4EL3MBTL1PTGS1PTGS2 | |
| SCHEMBL2086528 | 0.73 | PTGS1 (0.41) | GAAKDM4EL3MBTL1PTGS1PTGS2 | |
| SCHEMBL3716733 | 0.71 | PTGS1 (0.48) | GAAKDM4EPTGS1PTGS2EGLN1 | |
| SCHEMBL8605991 | 0.71 | KDM4E (0.47) | KDM4EL3MBTL1PTGS1PTGS2 | |
| SCHEMBL3367405 | 0.71 | PTGS1 (0.40) | GAAKDM4EPTGS1PTGS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126745-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-11-04 | — | — | WO | disclosed |