Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705174 | 0.79 | EGLN1 (0.54) | PTGS1PTGS2EGLN1GAAALDH1A1 | |
| SCHEMBL118584 | 0.75 | MEN1 (0.54) | PTGS1PTGS2EGLN1 | |
| SCHEMBL14655219 | 0.73 | KDM4E (0.47) | PTGS1PTGS2KDM4E | |
| SCHEMBL15223897 | 0.73 | KDM4E (0.44) | EGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL19389656 | 0.72 | MCHR1 (0.47) | EGLN1ALDH1A1KDM4E | |
| SCHEMBL28626437 | 0.72 | PTGS1 (0.59) | PTGS1PTGS2EGLN1ALDH1A1CYP2C9 | |
| SCHEMBL2638074 | 0.72 | PTGS1 (0.59) | PTGS1PTGS2EGLN1ALDH1A1KDM4E | |
| SCHEMBL870792 | 0.72 | PTGS1 (0.59) | PTGS1PTGS2EGLN1 | |
| SCHEMBL9753842 | 0.72 | PTGS1 (0.59) | PTGS1PTGS2EGLN1GAAALDH1A1 | |
| SCHEMBL3718312 | 0.71 | GAA (0.39) | PTGS1PTGS2EGLN1GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126745-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-11-04 | — | — | WO | disclosed |