SCHEMBL3718356

SCHEMBL3718356

O=C=NCCc1ccc2cc3ccccc3cc2c1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.42
CYP2A6 P11509 2/20 0.40
SIGMAR1 Q99720 1/20 0.40
HRH3 Q9Y5N1 1/20 0.39
MIF P14174 3/20 0.38
TRPA1 O75762 1/20 0.38
CYP2E1 P05181 1/20 0.38
HIF1A Q16665 1/20 0.38
CYP2A13 Q16696 1/20 0.38
EPAS1 Q99814 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
PYCR1 P32322 1/20 0.37
SLC13A5 Q86YT5 1/20 0.37
PDPK1 O15530 1/20 0.37
RAB9A P51151 1/20 0.36
SLC6A4 P31645 1/20 0.36
BCHE P06276 1/20 0.36
SOX18 P35713 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3716318 0.95 CYP1A2 (0.47) CYP1A2CYP2A6SIGMAR1HRH3MIF
SCHEMBL3723399 0.82 CYP1A2 (0.42) CYP1A2CYP2A6SIGMAR1HIF1APYCR1
SCHEMBL9163264 0.82 HDAC1 (0.51) CYP1A2CYP2A6SIGMAR1MIFHDAC1
SCHEMBL6804290 0.77 MIF (0.50) CYP1A2CYP2A6MIFTRPA1CYP2E1
SCHEMBL331135 0.77 MIF (0.48) CYP2A6MIFTRPA1CYP2E1HIF1A
SCHEMBL31417957 0.77 CYP1A2 (0.48) CYP1A2CYP2A6SIGMAR1PYCR1RAB9A
SCHEMBL3722387 0.77 CYP1A2 (0.48) CYP1A2CYP2A6SIGMAR1PYCR1RAB9A
Phenethyl Isocyanate SCHEMBL5918 0.75 MIF (0.63) CYP2A6MIFTRPA1CYP2E1HIF1A
SCHEMBL28223083 0.74 CFTR (0.42) CYP1A2HIF1AEPAS1HDAC1HDAC8
SCHEMBL3723760 0.74 HTR2A (0.46) CYP1A2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010112946-A1 ADAMANTANE BISUREA DERIVATIVES, METHOD OF PREPARATION AND APPLICATION IN ANION SENSING RUDJER BOSKOVIC INSTITUTE (HR) 2010-10-07 WO claimed
WO-2010112946-A1 ADAMANTANE BISUREA DERIVATIVES, METHOD OF PREPARATION AND APPLICATION IN ANION SENSING RUDJER BOSKOVIC INSTITUTE (HR) 2010-10-07 WO disclosed