Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.49 |
| ▸ | MC4R | P32245 | 4/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CALCA | P06881 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MC5R | P33032 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718372 | 1.00 | AKT1 (0.49) | AKT1MC4RHRH2HRH1KMT2A | |
| SCHEMBL3728445 | 0.90 | AKT1 (0.49) | AKT1MC4RHRH2HRH1KMT2A | |
| SCHEMBL3728447 | 0.90 | AKT1 (0.49) | AKT1MC4RHRH2HRH1KMT2A | |
| SCHEMBL3731039 | 0.81 | AKT1 (0.72) | AKT1 | |
| SCHEMBL3731036 | 0.81 | AKT1 (0.72) | AKT1 | |
| Hydrochloric Acid SCHEMBL3725200 | 0.81 | AKT1 (0.70) | AKT1 | |
| Hydrochloric Acid SCHEMBL3725195 | 0.81 | AKT1 (0.70) | AKT1 | |
| SCHEMBL2795737 | 0.80 | CYP3A4 (0.49) | AKT1MC4RHRH2HRH1KMT2A | |
| SCHEMBL2797172 | 0.80 | CYP3A4 (0.58) | AKT1MC4RCALCA | |
| SCHEMBL3721994 | 0.80 | AKT1 (0.49) | AKT1MC4RHRH2HRH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372842-B2 | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2242757-B1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | CHEK2, CHEK1, BUB1B | AKT1 567/4885MC4R 4760/4885HRH2 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.