Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10010131 | 0.79 | FFAR1 (0.45) | — | |
| SCHEMBL1707934 | 0.77 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL1707822 | 0.67 | PPARG (0.44) | — | |
| SCHEMBL3715877 | 0.57 | HTR2A (0.32) | SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL2912518 | 0.57 | KDR (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5749932 | 0.57 | KMT2A (0.58) | NPC1RAB9AGAAALDH1A1KDM4E | |
| SCHEMBL123749 | 0.57 | MAPK10 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18772775 | 0.57 | TNNI3K (0.59) | NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21281905 | 0.56 | MAPK10 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4941362 | 0.56 | MAPK10 (0.71) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |