Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | KDM4B | O94953 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932964 | 1.00 | HDAC1 (0.56) | HDAC1KDM1ACASP1KDM2BKDM4C | |
| SCHEMBL30614605 | 0.86 | KDM4C (0.65) | HDAC1KDM1AKDM2BKDM4CMAP4K4 | |
| SCHEMBL1758387 | 0.85 | KDM5B (0.52) | HDAC1KDM1AKDM4CMAP4K4TRPV1 | |
| SCHEMBL27962521 | 0.85 | MAP4K4 (0.57) | HDAC1KDM1ACASP1MAP4K4MAP2K4 | |
| SCHEMBL28856057 | 0.83 | MAP4K4 (0.54) | KDM4CMAP4K4KDM4BKDM5CKDM5B | |
| SCHEMBL1592852 | 0.82 | KDM4B (0.58) | CASP1MAP4K4KDM4BKDM5CKDM5B | |
| SCHEMBL1758489 | 0.81 | SCN10A (0.62) | KDM2BKDM4CMAP4K4KDM4BKDM5C | |
| SCHEMBL581356 | 0.81 | KDM4C (0.58) | HDAC1KDM1AKDM2BKDM4CTRPV1 | |
| SCHEMBL1076389 | 0.81 | KDM4B (0.45) | HDAC1KDM1AKDM2BKDM4CMAP2K4 | |
| SCHEMBL28907344 | 0.81 | KDM4B (0.56) | KDM4CMAP4K4KDM4BKDM5CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| CN-115443276-B | Pyridopyrimidinone derivatives and their use as arene receptor modulators | 东亚ST株式会社 | 2025-04-18 | — | — | CN | disclosed |
| CN-115443276-A | Pyridopyrimidinone derivatives and their use as modulators of aromatic hydrocarbon receptors | 东亚ST株式会社 | 2022-12-06 | — | — | CN | disclosed |
| CN-108473462-A | Pyrazoles-pyridine derivate as EAAT3 inhibitor | 豪夫迈·罗氏有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-107922381-A | PYRIDINE OR PYRIMIDINE DERIVATIVES | 豪夫迈·罗氏有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107709311-A | The carboxamides derivatives of 2 phenyl, 6 imidazolyl pyridines 4 and its purposes as EAAT3 inhibitor | 豪夫迈·罗氏有限公司 | 2018-02-16 | — | — | CN | disclosed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |