Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724051 | 0.92 | MTOR (0.71) | MTORPIK3CAPIK3CGCYP3A4 | |
| SCHEMBL3719403 | 0.89 | MTOR (0.69) | MTORPIK3CAPIK3CGCYP3A4 | |
| SCHEMBL3721912 | 0.89 | MTOR (0.72) | MTORPIK3CAPIK3CG | |
| SCHEMBL3725697 | 0.88 | MTOR (0.67) | MTORPIK3CAPIK3CGCYP3A4 | |
| SCHEMBL1431094 | 0.84 | PIK3CA (1.00) | MTORPIK3CAPIK3CG | |
| SCHEMBL628588 | 0.83 | MTOR (0.82) | MTORPIK3CAPIK3CG | |
| SCHEMBL3719804 | 0.83 | MTOR (0.57) | MTORPIK3CAPIK3CGCYP3A4 | |
| SCHEMBL3727473 | 0.82 | PIK3CA (0.59) | MTORPIK3CAPIK3CG | |
| SCHEMBL56279 | 0.80 | MTOR (0.74) | MTORPIK3CAPIK3CG | |
| SCHEMBL2529259 | 0.80 | PIK3CA (0.83) | MTORPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120987-A1 | RING FUSED, UREIDOARYL- AND CARBAMOYLARYL-BRIDGED MORPHOLINO-PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120987-A1 | RING FUSED, UREIDOARYL- AND CARBAMOYLARYL-BRIDGED MORPHOLINO-PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |