Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728227 | 0.90 | MTOR (0.55) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL3724095 | 0.88 | GAA (0.51) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL3797372 | 0.88 | RAF1 (0.53) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL3722456 | 0.78 | ATR (0.56) | MTORPIK3CARAF1BRAFPIK3CD | |
| SCHEMBL3726551 | 0.77 | MTOR (0.79) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL27940479 | 0.75 | MTOR (0.73) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL3724894 | 0.74 | MTOR (0.77) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL32400 | 0.73 | MTOR (1.00) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL3721523 | 0.72 | PIK3CA (0.75) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL28603707 | 0.72 | MTOR (0.54) | MTORPIK3CAPIK3CGPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |