Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728227 | 0.88 | MTOR (0.55) | RAF1BRAFATRMTORJAK2 | |
| SCHEMBL3718876 | 0.88 | MTOR (0.57) | RAF1BRAFATRMTORPIK3CA | |
| SCHEMBL3724095 | 0.86 | GAA (0.51) | RAF1BRAFATRMTORJAK2 | |
| SCHEMBL3722456 | 0.82 | ATR (0.56) | RAF1BRAFATRMTORPIK3CA | |
| SCHEMBL3802375 | 0.76 | PIK3CA (0.57) | MTORJAK2JAK3JAK1TYK2 | |
| SCHEMBL2573121 | 0.72 | XDH (0.46) | ATRJAK2NPSR1 | |
| SCHEMBL2369996 | 0.71 | PIK3CA (0.71) | MTORJAK2PIK3CAPIK3CG | |
| SCHEMBL10831202 | 0.70 | ATR (0.52) | RAF1BRAFATRMTORPIK3CA | |
| SCHEMBL3624404 | 0.70 | PIK3CA (0.75) | MTORPIK3CAPIK3CG | |
| SCHEMBL16078183 | 0.70 | RAF1 (1.00) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |