Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | NSD2 | O96028 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | GALK1 | P51570 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.59 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719796 | 0.86 | KMT2A (0.61) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL12562674 | 0.85 | MAPT (0.61) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL12562672 | 0.85 | MAPT (0.61) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL1822228 | 0.83 | PIK3CA (0.73) | KMT2AMAPTAPAF1NSD2LMNA | |
| SCHEMBL3728412 | 0.82 | KMT2A (0.83) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL31549907 | 0.80 | KMT2A (0.65) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL4774559 | 0.78 | KMT2A (0.48) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL629664 | 0.77 | MAP3K12 (0.47) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL31205519 | 0.77 | MAPT (0.52) | KMT2AMEN1MAPTAPAF1NSD2 | |
| SCHEMBL13153214 | 0.77 | KMT2A (0.74) | KMT2AMEN1MAPTAPAF1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |