Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721661 | 0.81 | DYRK1A (0.37) | CSNK2A2CSNK2BFFAR4SCN10A | |
| SCHEMBL2773536 | 0.81 | SCN9A (0.41) | NR1H4DPP4DPP7HSD17B13ALDH1A1 | |
| SCHEMBL3717605 | 0.77 | NPC1 (0.41) | DPP4DPP7KITKDRFLT3 | |
| SCHEMBL13733937 | 0.67 | NR1H4 (0.46) | NR1H4DPP4DPP7HSD17B13KIT | |
| SCHEMBL13732616 | 0.64 | GPBAR1 (0.51) | NR1H4HSD17B13ALDH1A1L3MBTL1 | |
| SCHEMBL27936868 | 0.64 | NR1H4 (0.55) | NR1H4HSD17B13FFAR4SCN10A | |
| SCHEMBL3717348 | 0.64 | DPP4 (0.39) | DPP4DPP7KITKDRFLT3 | |
| SCHEMBL2774303 | 0.63 | EGLN1 (0.46) | — | |
| SCHEMBL2774499 | 0.63 | MAPT (0.48) | ALDH1A1 | |
| SCHEMBL13734803 | 0.62 | LMNA (0.57) | NR1H4ALDH1A1L3MBTL1SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |