SCHEMBL3719232

SCHEMBL3719232

CCCCOC(=O)CC(NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CTSK P43235 11/20 0.51
CTSS P25774 3/20 0.49
ITGB3 P05106 1/20 0.47
ITGA2B P08514 1/20 0.47
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HTT P42858 1/20 0.44
PPARA Q07869 2/20 0.40
PPARG P37231 1/20 0.40
CAPN1 P07384 1/20 0.40
IDO1 P14902 1/20 0.40
CYP2D6 P10635 1/20 0.40
SUCNR1 Q9BXA5 1/20 0.39
ACE P12821 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8176917 1.00 CTSK (0.51) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL4058903 1.00 CTSK (0.51) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL16328959 0.89 CTSK (0.49) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL16855041 0.89 CTSK (0.51) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL16552425 0.89 CTSK (0.51) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL1161276 0.89 CTSK (0.45) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL4364211 0.89 CTSK (0.45) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL12369655 0.86 CTSK (0.52) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL12228690 0.86 CTSK (0.52) CTSKCTSSITGB3ITGA2BCYP1A2
SCHEMBL13577832 0.86 CTSK (0.52) CTSKCTSSITGB3ITGA2BCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015094444-A1 SUGAR-FREE SWEETENER BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2015-06-25 WO disclosed
EP-2396304-A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY Exelixis, Inc. (US) 2011-12-21 EP disclosed
EP-2366693-A1 NITROIMIDAZOLE-AMINO ACID COMPOUND TYPE NUCLIDE HYPOXIA IMAGING AGENT AND INTERMEDIATES FOR PREPARING THEM Ruan, Jianping (CN) 2011-09-21 EP disclosed
WO-2010093845-A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY EXELIXIS, INC. (US) 2010-08-19 WO disclosed
EP-1263756-A2 BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA Bristol-Myers Squibb Pharma Company (US) 2002-12-11 EP disclosed
WO-2001070734-A2 BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-09-27 WO disclosed