Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719496 | 0.90 | IGF1R (0.46) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3719614 | 0.88 | IGF1R (0.44) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3718247 | 0.88 | IGF1R (0.44) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3759198 | 0.85 | INSR (0.47) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3726694 | 0.85 | IGF1R (0.48) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3763966 | 0.83 | IGF1R (0.52) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3720310 | 0.81 | CDK19 (0.44) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3721565 | 0.81 | IGF1R (0.55) | IGF1RERBB2EGFRINSRMAPK14 | |
| SCHEMBL3761148 | 0.79 | CDK19 (0.44) | IGF1RERBB2EGFRCDK19ALK | |
| SCHEMBL3721467 | 0.79 | CDK2 (0.51) | IGF1RERBB2EGFRCDK19ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138575-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | claimed |
| WO-2010138575-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |