Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ADH5 | P11766 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711194 | 0.87 | HDAC1 (0.56) | KAT6AABCB1CTSA | |
| SCHEMBL3715166 | 0.85 | EGFR (0.53) | AXLCYP11B2CYP11B1KAT6AABCB1 | |
| SCHEMBL2515900 | 0.85 | CTSA (0.53) | MKNK1MKNK2KMOHCAR2CYP11B2 | |
| SCHEMBL2259194 | 0.84 | HCAR2 (0.54) | MKNK1MKNK2AXLKMOHCAR2 | |
| SCHEMBL2262047 | 0.81 | KDM1A (0.59) | MKNK1MKNK2HCAR2DHODHKDM4E | |
| SCHEMBL569730 | 0.81 | MKNK1 (0.69) | MKNK1MKNK2KMOHCAR2DHODH | |
| SCHEMBL2900222 | 0.77 | MKNK1 (0.68) | MKNK1MKNK2HCAR2KDM4ELMNA | |
| SCHEMBL31475536 | 0.76 | HCAR2 (0.56) | MKNK1MKNK2AXLKMOHCAR2 | |
| SCHEMBL25544943 | 0.76 | HCAR2 (0.56) | MKNK1MKNK2AXLKMOHCAR2 | |
| SCHEMBL21652631 | 0.74 | MKNK1 (0.51) | MKNK1MKNK2KMOHCAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |