Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719632 | 0.85 | MKNK1 (0.52) | CYP11B1CYP11B2CTSAAXLKAT6A | |
| SCHEMBL9008962 | 0.84 | CYP11B1 (0.61) | EGFRCYP11B1CYP11B2CYP2A6SGK1 | |
| SCHEMBL3711194 | 0.84 | HDAC1 (0.56) | CTSAKAT6AABCB1 | |
| SCHEMBL1051864 | 0.80 | CYP2A6 (0.50) | CYP11B1CYP11B2CYP2A6ATMPDGFRB | |
| SCHEMBL2906199 | 0.78 | CYP11B1 (0.62) | CYP11B1CYP11B2CYP2A6ATMNPC1 | |
| SCHEMBL30702670 | 0.77 | EGFR (0.61) | EGFRPDK2NPC1RAB9AACLY | |
| SCHEMBL3709350 | 0.77 | KDM4E (0.56) | EGFRSGK1CAMKK2GABRG2GABRB3 | |
| SCHEMBL3713278 | 0.76 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP2A6SGK1CAMKK2 | |
| SCHEMBL1054060 | 0.76 | CYP11B2 (0.62) | CYP11B1CYP11B2CYP2A6ATM | |
| SCHEMBL13188366 | 0.76 | CYP11B1 (0.67) | CYP11B1CYP11B2CYP2A6SLC2A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |