Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713649 | 0.87 | HDAC1 (0.52) | HDAC6HDAC1MAPTFFAR1HDAC2 | |
| SCHEMBL400670 | 0.85 | HDAC1 (0.60) | HDAC6HDAC1FFAR1KDM1A | |
| SCHEMBL3714223 | 0.81 | ALDH1A1 (0.62) | MAPTGRM5CSF1R | |
| SCHEMBL3710305 | 0.81 | HDAC6 (0.51) | HDAC6HDAC1FFAR1HDAC2HDAC8 | |
| SCHEMBL13187784 | 0.79 | CSF1R (0.53) | HDAC6HDAC1HDAC2HDAC3CSF1R | |
| SCHEMBL13187673 | 0.79 | CSF1R (0.46) | HDAC6HDAC1HDAC2HDAC3GRM5 | |
| SCHEMBL13187782 | 0.77 | HDAC6 (0.46) | HDAC6HDAC1FFAR1GRM5AAK1 | |
| Nicoxamat SCHEMBL93839 | 0.77 | HDAC1 (1.00) | HDAC6HDAC1MAPTHDAC2HDAC8 | |
| SCHEMBL3714897 | 0.77 | HDAC1 (0.52) | HDAC6HDAC1FFAR1HDAC2HDAC8 | |
| Nicoxamat SCHEMBL28301679 | 0.76 | HDAC1 (0.96) | HDAC6HDAC1MAPTHDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |