Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.78 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | AXL | P30530 | 4/20 | 0.61 |
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | MERTK | Q12866 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | CDK11B | P21127 | 1/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693564 | 0.97 | MET (0.84) | METKDRAXLEGFRFLT3 | |
| SCHEMBL4403397 | 0.97 | MET (0.84) | METKDRAXLEGFRFLT3 | |
| SCHEMBL17867476 | 0.89 | MET (0.77) | METKDRAXLEGFRFLT3 | |
| SCHEMBL15279409 | 0.89 | MET (0.72) | METKDRAXLEGFRFLT3 | |
| SCHEMBL23430677 | 0.89 | MET (0.71) | METKDRAXLEGFRFLT3 | |
| SCHEMBL371651 | 0.88 | MET (1.00) | METKDRAXLEGFRFLT3 | |
| SCHEMBL29693453 | 0.88 | MET (1.00) | METKDRAXLEGFRFLT3 | |
| SCHEMBL19373165 | 0.87 | MET (0.88) | METKDRAXLEGFRFLT3 | |
| SCHEMBL17867475 | 0.87 | MET (0.73) | METKDRAXLEGFRFLT3 | |
| SCHEMBL4401192 | 0.86 | MET (0.83) | METKDRAXLEGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-1673085-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2011-11-09 | — | — | EP | disclosed |
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |