Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727310 | 0.92 | MTOR (0.58) | MTORPIK3CACYP3A4PIK3CG | |
| SCHEMBL3720999 | 0.88 | MTOR (0.57) | MTORPIK3CACYP3A4PIK3CG | |
| SCHEMBL3727062 | 0.88 | MTOR (0.55) | MTORPIK3CACYP3A4PIK3CG | |
| SCHEMBL3722235 | 0.87 | MTOR (0.59) | MTORPIK3CACYP3A4PIK3CG | |
| SCHEMBL3722622 | 0.84 | MTOR (0.57) | MTORPIK3CACYP3A4PIK3CG | |
| SCHEMBL3719804 | 0.84 | MTOR (0.57) | MTORPIK3CACYP3A4PIK3CG | |
| SCHEMBL3722849 | 0.83 | MTOR (0.60) | MTORPIK3CA | |
| SCHEMBL3719574 | 0.81 | MTOR (0.54) | MTORPIK3CAPIK3CG | |
| SCHEMBL3723078 | 0.80 | MTOR (0.56) | MTORPIK3CAPIK3CG | |
| SCHEMBL3718679 | 0.80 | MTOR (0.59) | MTORPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120991-A1 | 5, 6, 7, 8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR, PI3, AND HSMG-1 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120991-A1 | 5, 6, 7, 8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR, PI3, AND HSMG-1 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |