SCHEMBL3720205

SCHEMBL3720205

CC(=O)c1ccc2cc(Oc3ccc(Oc4ccncc4)cc3Cl)ccc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESRRA P11474 3/20 0.52
MAPT P10636 2/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
MAPK14 Q16539 2/20 0.42
PARG Q86W56 3/20 0.42
PARP1 P09874 1/20 0.41
CHEK2 O96017 3/20 0.41
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
MAPK1 P28482 1/20 0.40
KDR P35968 1/20 0.39
PNLIP P16233 1/20 0.39
SCN9A Q15858 2/20 0.39
SCN7A Q01118 1/20 0.39
KCNH2 Q12809 1/20 0.39
ALDH1A1 P00352 2/20 0.38
CYP3A4 P08684 1/20 0.38
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3721318 0.86 ESRRA (0.48) ESRRAMAPTCHEK2KDM4EMAPK1
SCHEMBL3725192 0.84 ESRRA (0.56) ESRRAMAPTHPGDPARGPARP1
SCHEMBL3719235 0.84 MEN1 (0.58) ESRRAMAPTHPGDRAB9APARG
SCHEMBL3719884 0.83 ESRRA (0.51) ESRRAMAPTHPGDRAB9ACHEK2
SCHEMBL3719330 0.82 ESRRA (0.60) ESRRAMAPTHPGDRAB9APARG
SCHEMBL3722825 0.81 ESRRA (0.48) ESRRAMAPTPARGPARP1SCN7A
SCHEMBL3726992 0.81 ESRRA (0.53) ESRRAMAPTPARGPARP1KDM4E
SCHEMBL3718519 0.80 ESRRA (0.47) ESRRAMAPTPARGPARP1CHEK2
SCHEMBL3724748 0.78 ACACB (0.47)
SCHEMBL3724749 0.78 ACACB (0.45) MAPTHPGDMAPK14KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010127208-A1 INHIBITORS OF ACETYL-COA CARBOXYLASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-11-04 WO disclosed