Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14559946 | 0.79 | KDM4E (0.46) | HPGDTSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL111791 | 0.72 | CDK4 (0.48) | HPGDMAPTKDM4EPOLBALDH1A1 | |
| SCHEMBL1132593 | 0.70 | TSHR (0.61) | HTR1AHTR7HPGDTSHRKDM4E | |
| SCHEMBL20320421 | 0.70 | MAPT (0.67) | CREBBPHTR1AHTR7HPGDMAPT | |
| SCHEMBL111483 | 0.69 | CHEK1 (0.51) | HPGDTSHRMAPTBRD4KDM4E | |
| SCHEMBL18812499 | 0.69 | BRD4 (0.51) | TSHRBRD4ALDH1A1ESR2 | |
| SCHEMBL3716370 | 0.69 | POLB (0.51) | CREBBPHTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL1233435 | 0.69 | USP8 (0.35) | CREBBPHPGDTSHRMAPTKDM4E | |
| SCHEMBL27909137 | 0.68 | ESR2 (0.52) | TSHRKDM4EALDH1A1ESR2GABRG2 | |
| SCHEMBL2186547 | 0.68 | TSHR (0.59) | HTR1AHTR7TSHRKDM4EESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |