Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711872 | 0.90 | KDM4E (0.42) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3711417 | 0.88 | MMP13 (0.43) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3713497 | 0.88 | KDM4E (0.40) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3713860 | 0.85 | MAPK14 (0.41) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3793389 | 0.82 | KCNH2 (0.42) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3716111 | 0.81 | KDM4E (0.42) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3709419 | 0.79 | PARP1 (0.45) | MMP13MMP2MMP8MMP9 | |
| SCHEMBL3708590 | 0.78 | KDM4E (0.41) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3721263 | 0.78 | TACR2 (0.42) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3714253 | 0.74 | HDAC1 (0.52) | MMP13MMP2MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |