Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31450301 | 1.00 | HCAR2 (0.39) | HCAR2POLBTSHRAKR1C4AKR1C3 | |
| SCHEMBL15758062 | 0.84 | HCAR2 (0.46) | HCAR2POLBTSHRAKR1C4AKR1C3 | |
| SCHEMBL31450217 | 0.83 | HCAR2 (0.31) | HCAR2POLB | |
| SCHEMBL31582632 | 0.82 | MAOB (0.35) | HCAR2POLBSMN1; SMN2 | |
| SCHEMBL392397 | 0.78 | TSHR (0.48) | HCAR2TSHRAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL659061 | 0.78 | HCAR2 (0.42) | HCAR2POLBTSHRAKR1C4AKR1C3 | |
| SCHEMBL31347599 | 0.77 | KDM4E (0.41) | TSHRALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL15334246 | 0.77 | AKR1C3 (0.50) | HCAR2POLBTSHRAKR1C4AKR1C3 | |
| SCHEMBL21749937 | 0.77 | HCAR2 (0.41) | HCAR2POLBTSHRAKR1C4AKR1C3 | |
| SCHEMBL16694995 | 0.75 | HCAR2 (0.39) | HCAR2POLBTSHRAKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| EP-2041111-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008002247-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |