Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN7A | Q01118 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722566 | 1.00 | SCN7A (0.48) | SCN7AKCNH2SCN5ASCN2ASCN8A | |
| SCHEMBL3717667 | 0.85 | MAPT (0.34) | SCN7AKCNH2SCN5APDE10AMAP4K4 | |
| SCHEMBL3720645 | 0.83 | MAPT (0.39) | MAP4K4 | |
| SCHEMBL3719589 | 0.82 | MAPT (0.34) | SCN7AKCNH2SCN5ASCN2ASCN8A | |
| SCHEMBL3720723 | 0.82 | MAPT (0.44) | MAP4K4 | |
| SCHEMBL3720739 | 0.81 | MAPT (0.39) | SCN5ASCN9AP2RX3 | |
| SCHEMBL3720742 | 0.81 | MAPT (0.37) | SCN7AKCNH2SCN9AP2RX3PDE4B | |
| SCHEMBL3724195 | 0.81 | MCHR1 (0.40) | DRD1 | |
| SCHEMBL3720648 | 0.81 | MAPT (0.36) | SCN7AKCNH2P2RX3 | |
| SCHEMBL3717035 | 0.80 | SCN7A (0.46) | SCN7AKCNH2SCN5ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |