Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 4/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724195 | 0.91 | MCHR1 (0.40) | MAPTTLR8ALDH1A1KDM4E | |
| SCHEMBL3718572 | 0.88 | PNLIP (0.40) | MAPTLMNAMAPK1HIF1ANCF1 | |
| SCHEMBL3722045 | 0.88 | MAPT (0.38) | MAPTLMNAMAPK1HIF1ANCF1 | |
| SCHEMBL3720723 | 0.87 | MAPT (0.44) | MAPTTLR8MAP4K4ALDH1A1ACACB | |
| SCHEMBL3720292 | 0.86 | MAPT (0.41) | MAPTLMNAMAPK1HIF1ANCF1 | |
| SCHEMBL3720739 | 0.85 | MAPT (0.39) | MAPTALDH1A1RAB9AKMT2AGAA | |
| SCHEMBL3717667 | 0.84 | MAPT (0.34) | MAPTMAP4K4ALDH1A1POLB | |
| SCHEMBL3720648 | 0.84 | MAPT (0.36) | MAPTGPBAR1CYSLTR1ALDH1A1 | |
| SCHEMBL3722566 | 0.83 | SCN7A (0.48) | MAP4K4 | |
| SCHEMBL3720550 | 0.83 | SCN7A (0.48) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |