Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715747 | 0.98 | JAK3 (0.43) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL3712540 | 0.89 | JAK3 (0.48) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL3715479 | 0.82 | JAK3 (0.46) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL912904 | 0.82 | JAK3 (0.52) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL914114 | 0.81 | JAK3 (0.51) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL3720779 | 0.80 | JAK2 (0.39) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL913843 | 0.80 | JAK3 (0.52) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL914828 | 0.79 | JAK3 (0.51) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL913948 | 0.79 | IRAK4 (0.65) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL913949 | 0.79 | IRAK4 (0.65) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |